Information processing of a single neuron

“He is never less at leisure than when at leisure, nor less alone than when he is alone.” - Cicero

We observe calcium dynamics in dendrites of neurons to elucidate its functional significance. A neuron is considered to be an elementary unit of information processing in brains, and composed of a soma, an axon, and dendrites. Dendrites receive and integrate information from many neurons. Therefore, for revealing mechanisms of information processing in brains, it is indispensable to scrutinize dendrite activities. When, where and how do dendrites receive input from other cells? How is the input integrated then? Even such fundamental questions have not been answered yet. That is because it has been technically difficult to investigate dendrite activities in brains so far. Accordingly, we develop our original methods to make it possible, such as the two-photon imaging method and the fiberoptic imaging method, in order to challenge these issues.