Synaptic transmission between two cells

“If you do not know a man, look at his friends.”
- Confucius

Our target is to elucidate signal transduction between two neurons and neural mechanisms to support it. For example, do mental states of animals change synaptic transmission efficiency? To answer this question, activities of “anterior” neurons that provide output and “posterior” neurons that receive it need to be recorded simultaneously. For investigating activities of neurons, intracellular recording is appropriate. This method can measure membrane potential response in detail. As an additional advantage, pigment can be injected into cells, and thus it enables us to identify species of recorded neurons by morphology of stained cells. Although it is not easy to stably record activities of multiple neurons simultaneously from brains of animals in states of action, we are working on constructing a recording system that makes this possible.